TSH Test: What Your Thyroid Stimulating Hormone Means

TSH is the most common screening test for thyroid function. Learn what high and low TSH means, typical ranges, and when to check free T4 and free T3.

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What it is

TSH stands for thyroid stimulating hormone. It is made by the pituitary gland in your brain and tells your thyroid how much hormone to produce. When thyroid hormone is low, TSH rises. When thyroid hormone is high, TSH drops.

TSH is usually the first test doctors order because it is sensitive. If TSH is abnormal, free T4 and sometimes free T3 are checked to see how the thyroid is actually performing.

Why it matters

Thyroid hormone regulates metabolism, energy, body temperature, mood, heart rate, digestion, and menstrual cycles. An underactive thyroid can cause fatigue, weight gain, cold intolerance, constipation, and low mood. An overactive thyroid can cause anxiety, weight loss, heat intolerance, and rapid heartbeat.

Women are several times more likely than men to develop thyroid conditions, and pregnancy and postpartum can significantly affect TSH.

Typical reference ranges

Ranges vary by lab and individual circumstances. These are common adult reference ranges for orientation only.

GroupCommon range
Typical adult reference0.4–4.0 mIU/LSome labs use up to 4.5
Optimal for many adults0.5–2.5 mIU/LIndividual target varies
High TSH> 4.0–4.5 mIU/LOften suggests hypothyroidism
Low TSH< 0.4 mIU/LOften suggests hyperthyroidism

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Where it comes from

TSH is not something you get from food. It is a hormone your body makes. Iodine, however, is essential for thyroid hormone production. Iodine is found in iodized salt, seafood, dairy, and eggs. Both too little and too much iodine can affect thyroid function.

What can move your result

Age, sex, pregnancy, postpartum changes, autoimmune disease, iodine intake, medications such as lithium or amiodarone, and pituitary issues can all affect TSH. High or low TSH should be interpreted alongside free T4 and symptoms.

Frequently asked questions

What does high TSH mean?
High TSH usually means your thyroid is underactive (hypothyroidism). Your brain is making more TSH to try to stimulate the thyroid into producing more hormone.
What does low TSH mean?
Low TSH usually means your thyroid is overactive (hyperthyroidism), or that you are taking too much thyroid medication. Your brain reduces TSH because thyroid hormone levels are high.
Should I test TSH fasting?
TSH can vary slightly during the day, but fasting is usually not required. Many clinicians prefer morning testing for consistency.

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