Hemoglobin
The oxygen-carrying protein inside red blood cells. It is the single best number for spotting anemia.
- If it is high
- Often dehydration, smoking, sleep apnea, or living at altitude. Persistently high values are investigated for overproduction of red cells.
- If it is low
- Anemia. Iron deficiency is the most common cause, followed by B12 or folate deficiency, blood loss, and chronic disease. Symptoms include fatigue, breathlessness, and cold hands.